Natural plant-based steroids from Smilax Sieboldii

Smilax Sieboldii is a climbing shrub which mainly grows in East Asia, and South and North America [1]. Its young leaves are used for food and the subterranean parts have been used in Traditional Chinese Medicine (TCM) for arthritis, tumors and lumbago [2, 3]. This plant has aroused researches tremendous attention because of a natural steroidal sapogenin- laxogenin [4]. Laxogenin is a spirostanic analogue of brassinosteroid, shown to possess an anabolic/androgenic activity similar to one of the most efficient anabolic substances, anavar, yet without the side effects of liver toxicity or likelihood of testing positive for steroid [5].

5α-Hydroxy Laxogenin, a homolog of laxogenin, is also a natural steroids in green plant [6]. In the earliest time, both two plant-based steroids are sold in the market, while with the time being, consumers prefer to choose 5α-Hydroxy Laxogenin. They strongly reflected that 5α-Hydroxy Laxogenin had a better anabolic effect on their body than laxogenin, although the mechanism needs further studied.

What is Laxosterone®

Laxosterone® is the trademark of 5α-Hydroxy Laxogenin from BESTCOM. Due to very less content in nature plant, we create a green bioconversion method to get a highly purified 5α-Hydroxy Laxogenin from nature plant materials. Meanwhile, we developed a new microencapsule 5α-Hydroxy Laxogenin, with very good bioavailability.

Highlight of Laxosterone®

However, its application was blocked by a surge of fake raw materials since 2010. We have tested different origins of 5α-Hydroxy Laxogenin from the market, content are all very low, only from 20-55%, even some are not 5-alpha Hydroxy Laxogenin at all.

HPLC Test For Different Laxogenin Origins From Market

Benefits of Laxosterone®

According to a Russian research, 5α-Hydroxy Laxogenin could accelerate the gain of weight in rats by increasing the weight of the liver, heart, kidneys, musculus tibiliasis anterior and augmenting the total amount of protein therein as well. All of the above-mentioned changes become more pronounced with the study substance introduced to young animals [6].
Date also indicated that 5α-Hydroxy Laxogenin, used by athletes, produced dramatic strength increases in 3-5 days, and muscle mass increases in 3-4 weeks. The increase of protein synthesis by over 200% was the key to lean muscle growth and accelerated repair. Further investigation of the molecule showed that it could also balance cortisol response which is the major cornerstone for recovery and reduction of muscle wasting [7, 8].

A double-blind study of laxogenin and 5α-Hydroxy Laxogenin on athletic performance is shown below. One hundred healthy male body builder volunteered for the 4-week double-blind study during an intensive training period. The subjects were randomly divided into three groups and assigned to receive 5α-Hydroxy Laxogenin, laxogenin and placebo (isomaltulose) everyday, respectively. The daily training schedule included barbell bench press, barbell bicep curls, seated leg press and seated leg press at 65% of the maximum exercise. Meanwhile, upper arm circumference, bust, thigh circumference were measured weekly. During the period, nobody was allowed to try out a new supplement or drug. The daily food should not be changed suddenly, and protein intake should remain constant. The results appeared as shown below. As compared to placebo, 5α-Hydroxy Laxogenin supplementation had a significant effect on increase strength and endurance, broader arms, legs and shoulders. So we believe in that 5α-Hydroxy Laxogenin can help you to build a stronger and healthier body.

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